Now Open:
Women’s Health Fund IV
Members Only Access: Women’s Health Fund IV
Women’s health is a $1 trillion+ market, and Fund IV targets the next wave of innovative solutions in fertility, menopause, mental health, longevity, and more. With our proven track record, Fund IV gives you the opportunity to back game-changing companies defining the future of women’s health.
Before opening the fund to new investors, we’re extending early access to you, our existing investors, to continue driving impact and returns in one of the most underserved markets in healthcare. Let’s continue to shape the future of women’s health together.
Women’s Health Fund IV Overview— Meet the Partners
AUGUST 13 AT 9:30 AM PST
We’re excited to invite you to a special members-only event on Wednesday, August 13 at 9:30 AM PT as we officially launch Portfolia’s Women’s Health Fund IV—our most focused and forward-looking strategy yet in women’s health innovation.
OUR FIRST INVESTMENT
Gameto, a biotech company reprogramming female cells, is addressing critical gaps in fertility and hormonal care. Investing in Fund IV means supporting companies like Gameto that are tackling the $1 trillion opportunity in women’s health.
Quick Facts:
Fertilo, Gameto’s lead program, is set to revolutionize IVF and egg-freezing by making the process faster, safer, and more effective.
Fertilo has received FDA tentative approval for Phase 3 trials, a major step toward U.S. commercialization. Fertilo is already being used clinically in Australia and Latin America, with 9 babies born to date.
Gameto is making significant strides in women's health technology, particularly in fertility treatments.
WHY INVEST NOW?
Women’s health represents a $1 trillion+ market, yet it remains one of the most underserved sectors in healthcare. Despite women making 80% of healthcare decisions, only 2% of VC funding goes to this space. Women’s Health Fund IV provides a unique opportunity to drive strong returns while transforming healthcare for women. And, as an existing investor in a Portfolia fund, you have exclusive, early access to invest in the fund before it’s opened to new investors.
WOMEN’S HEALTH FUND PORTFOLIO HIGHLIGHT
Maven Clinic becomes the first U.S. 'unicorn' dedicated to women's and family health, and Kate and Maven are just hitting their stride.
THE PARTNERS
Led by Experts in Women’s Health and Venture Capital. Backed by decades of experience, our fund advisors source and vet opportunities with scientific rigor and strategic vision. Portfolia Partners are selected to join a fund because of their expertise and investment history in the relevant space, deep networks of co-investors and entrepreneurs, and their ability to add value to portfolio companies over the life of the investment. Fund Partners are best-in-class investors, with an average of 15+ years of investing experience.
TRISH COSTELLO
Founder and CEO of Portfolia, Trish Costello is a trailblazing Silicon Valley investor and entrepreneur. She previously led the Kauffman Fellows Program and founded CVE Capital Corp., with over $1.7B under management. Recognized globally for her leadership in venture education and women’s investing, she was named Springboard Investor of the Year, Business Insiders Top Ten Early Stage Investors in 2024 and 2025, and Entrepreneur Magazine’s Top 100 Innovative Women Leaders.
NOLA MASTERSON, MSc.
A biotech pioneer with 45+ years of experience, Nola was the first biotech analyst on Wall Street and co-founded Sequenom, Inc. She has launched and advised numerous life sciences companies and served on multiple public and private boards. A long-time Portfolia leader, she brings deep venture expertise, board governance, and a global leadership perspective to Women’s Health investing.
FAZ K. BASHI, MD
Dr. Faz Bashi is a leader in life sciences investing with a background in immunology and virology. He has chaired multiple angel screening committees, led investments for Portfolia’s FemTech funds, and supports women entrepreneurs through Springboard Enterprises. He is a passionate advocate for innovation in diagnostics, digital health, and inclusive venture funding.
SONIA ARRISON
Sonia Arrison is a longevity investor, author of 100 Plus, and founder of 100 Plus Capital. She serves on boards like the Foresight Institute and Alliance for Longevity Initiatives, and advises Felicis Ventures. A leader at the intersection of tech and aging, Sonia brings deep expertise in life extension, societal innovation, and investing in transformative aging solutions.
JENNIFER FRIED, MBA
Jennifer Fried is CEO and co-founder of Flow Medical and a veteran venture-backed founder with an exit under her belt. She served as CEO of Explorer Surgical and teaches entrepreneurship at Booth School of Business. An early-stage investor and Portfolia fund partner since 2018, Jennifer brings operational expertise, VC insight, and a mission-driven focus on healthcare innovation.
DELPHINE O’ROURKE, JD
Delphine O’Rourke is a healthcare lawyer, strategist, and investor focused on women’s health innovation. With 20+ years of experience across legal, regulatory, and executive roles, she advises startups and boards globally. She brings critical expertise in healthcare policy, investment diligence, and advancing equitable solutions for women’s health.
PROVEN TRACK RECORD
Fund IV builds on our global leadership, optimizing returns and driving meaningful impact in women’s health. We identify top talent that deliver breakthrough value and exceptional growth. This remarkable success stems not from a single company but reflects the strength and execution of a well-founded thesis. The Women’s Health Fund IV will invest in top early to growth-stage companies across all sectors.
Our Focus Areas
Women-specific Conditions: Contraception, Fertility, Maternal Health, Menopause, Gynecology & Women’s Oncology
Conditions that Affect Women Differently: Cardiovascular Disease, Diabetes, Alzheimer’s Disease
Conditions that Affect Women Disproportionally: Autoimmune Disease, Osteoporosis, Anxiety and Depression, Lung Cancer, Eating Disorders
FAQs
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Active Aging & Longevity Fund I is currently at 1.2x TVPI (Multiple) with a Projected TVPI of 2.8x
FemTech Fund I is currently at 1.02X TVPI with a projected TVPI of 3.10x
Active Aging & Longevity Fund II is currently at 1.18x TVPI with a projected TVPI of 2.7x.
FemTech Fund II is currently at a 1.79x with a Projected TVPI of 2.8x
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Portfolia is the recognized leader in the women's health sector and the most active investor globally in women’s health with 44 women’s health companies in its portfolio and has invested in 66 healthcare companies across all Portfolia funds.
The current portfolio of women’s health companies is strong, innovative, and scaling. Building on history, reputation and momentum, Portfolia commands a robust pipeline with unique deal flow and singular expertise in the marketplace, translating into growing opportunities in women's health and longevity, across all stages.
Portfolia investments include:
Maven Clinic – $1.7B global virtual clinic for women
Everly Health – $3B+ diagnostics-driven care through at-home lab tests
Mirvie – RNA platform for early detection of preeclampsia
Lighthouse Pharma – Breakthrough solutions for Dementia/Alzheimers
Frontier Bio – Developing lab-grown human tissue
Mercy Bioanalytics – Blood test for early detection of ovarian cancer
Bone Health – The first FDA approved solution for osteopenia
YourChoice – First non-hormonal male birth control pill
Hera Biotech – Non-invasive diagnostic for endometriosis and cervical cancer
Gameto – Breakthrough cell engineering targeting infertility and menopause
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Women’s Health Fund Portfolia Partners are selected to join a fund because of their expertise and investment history in the relevant space, deep networks of co-investors and entrepreneurs, and their ability to add value to portfolio companies over the life of the investment. Fund Partners are best-in-class investors, with an average of 15+ years of investing experience.
Women’s Health IV Fund Partners:
Trish Costello - Managing Director
Nola Elizabeth Masterson, MSc. (FemTech I, II & III)
Faz K. Bashi, MD (FemTech I, II & III)
Jennifer Fried, M.B.A (FemTech I, II & III)
Sonia Arrison (Active Aging II)
Delphine O’Rourke, JD (FemTech III)
Fund Partners are geographically located in every major innovation hub in the US.
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Portfolia Women’s Health Fund IV is the next evolution in its proven, category-defining investment strategy backing high-growth, high-impact innovations that are transforming the health and wellness of women across every stage of life.
Building on five successful prior funds in FemTech and Active Aging, Fund IV will invest in the most promising early to growth-stage companies at the intersection of science, technology, and female biology.
Women make up half the population, control 80% of healthcare decisions, and account for over $15 trillion in global spending power, yet only 2% of venture funding in healthcare goes toward solutions built for their unique needs. Portfolia is here to change that.
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Portfolia provides the back office, structure and limited partner support so the world's top VCs can focus on investing.
Portfolia's 46 partners across 14 funds lead the industry's best practice, and provide an expert investing network across industry
Portfolia's 2,000 limited partner executive, across all 50 states and 20 countries, provide unparalleled knowledge, networks, and expertise.